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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. B8210 PFI-2 (hydrochloride)
  3. B3276 MG 149 HAT inhibitor
  4. B3274 CCT007093 PPM1D inhibitor
  5. B3272 Inauhzin SIRT1 inhibitor
  6. B4890 HPOB HDAC6 inhibitor, potent and selective
  7. B7594 Salermide SIRT1 and SIRT2 inhibitor
  8. B7323 AGK 2 SIRT2 inhibitor, potent and selective
  9. B1577 C646 HAT p300-CBP inhibitor,cell-permeable
  10. B1177 Nafamostat Broad spectrum serine protease inhibitor, kallikrein inhibitor
  11. B1259 (3R,4S)-Tofacitinib Novel inhibitor of JAK3

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