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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. Product Name Information
  2. B4950 Darunavir Ethanolate nonpeptidic HIV protease inhibitor
  3. B2084 Cathepsin Inhibitor 1 Cathepsin inhibitor
  4. A1902 Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor
  5. B2208 Ramipril angiotensin-converting enzyme (ACE) inhibitor
  6. B2204 Enalaprilat Dihydrate angiotensin-converting enzyme (ACE) inhibitor
  7. B1037 Alvelestat NE inhibitor
  8. A8650 Saxagliptin Selective DPP4 inhibitor
  9. A8622 Bestatin trifluoroacetate Aminopeptidase / CD13 inhibitor
  10. A8621 Bestatin hydrochloride Inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
  11. A8420 Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent

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